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. Author manuscript; available in PMC: 2010 Jan 8.
Published in final edited form as: Regul Pept. 2008 Jul 16;152(1-3):33–40. doi: 10.1016/j.regpep.2008.07.004

Figure 1. Pituitary adenylate cyclase activating peptide (PACAP) 38 protects cortical neurons against sodium nitroprusside (SNP) treatment.

Figure 1

Data represents cell survival as measured by MTT assay and expressed as percent of untreated control (100%). Data are means ± SEM of three or 4 experiments performed in triplicate. One-way Analysis of variance was performed followed by Newman-Keuls Multiple comparison test. A. SNP evokes neuronal cell death. Cortical neurons were treated with a range of SNP concentrations (10 μM – 1 mM) for 4 h. *** p <0.001 vs control. B. Cortical neurons were treated with 1 mM SNP and co-incubated with a range of PACAP38 concentrations (25 nM – 300 nM for 4 h). a p<0.01 vs control, ** p<0.01 vs 1 mM SNP. C. Cortical neurons were exposed to PACAP38 at the time of SNP (1 mM, 4 h) treatment (Co-treatment), or 1 h prior (Pre-treated), or 1 h after SNP treatment (Post-treatment).

a p<0.05 vs Control

* p<0.05 vs 1mM SNP.