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. 2009 Jan 6;169(4):505–514. doi: 10.1093/aje/kwn359

Table 6.

Effect on Mendelian Randomization of Both Deviations From Hardy-Weinberg Equilibrium and Additions of Missing Persons to Conform to Perfect Hardy-Weinberg Equilibriuma

Original Study Addition of Missing Personsb Addition of Missing Personsc Addition of Missing Personsd
MR Probability HWE χ2 MR Probability HWE χ2 MR Probability HWE χ2 MR Probability HWE χ2
0.0697 3.32 0.0477 0 2.91−16 0 7.54−30 0

Abbreviations: HWE, Hardy-Weinberg equilibrium; MR, Mendelian randomization.

a

Analyses were carried out in a study of 10,000 persons with information on a genetic marker, an intermediate trait, and a disease outcome.

b

Addition of 507 homozygote 1 subjects with a diseased status and a mean body mass index (weight (kg)/height (m)2) equal to that of subjects in the original study.

c

Addition of 507 homozygote 1 subjects with a diseased status and a body mass index greater than or equal to the highest 75th percentile of body mass index for subjects in the original study.

d

Addition of 507 homozygote 1 subjects with a diseased status and a body mass index greater than or equal to the highest 95th percentile of body mass index for subjects in the original study.