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. 2008 Dec 2;18(5):797–808. doi: 10.1093/hmg/ddn406

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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

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Figure 5. — C150S improves rod photoreceptor OS structure in rds^+/− retina. Shown are representative light (top) and electron (bottom) microscopy from retinal sections of MOP-T, COP-T and non-transgenic controls in the WT (A), rds^+/− (B) and rds^−/− (C) backgrounds. Eyes presented in A and B were taken from mice at P180 and in C from mice at P30. Expression of C150S-Rds had no effect on rod OS structure in the WT background and led to partial improvement in OS structure in the rds^+/− background. As expected, no change in rod OS structure was noticed in COP-T/rds^+/− or COP-T/WT retinas compared with non-transgenic controls. (C) Except in rare instances (arrow) C150S-Rds was not sufficient to support OS formation in the absence of endogenous Rds. RPE, retinal pigment epithelium; OS, outer segment; IS, inner segment; ONL, outer nuclear layer; INL, inner nuclear layer. Scale bar, 4 µm (EM) and 20 µm (light).