Table 1.
Chlamydia antigens recognized by infection-primed CD8+ T cells
| Protein | Chlamydia species | Predicted Localization | Number of epitopes (restricting MHC I allele) | Antigen Identification Method | CD8+ T cell recognition of infected cells | Reference |
|---|---|---|---|---|---|---|
| Omp2 (Cpn0557) | C. pneumoniae | Outer membrane | 4 (H-2 Kb, H-2 Db, H-2 Kd, H-2 Dd) | MHC I motif prediction | Yes, No | [24, 38] |
| DnaK (Cpn0503) | C. pneumoniae | Cytosolic, surface-exposed | 2 (H-2 Db, HLA-A*0201) | MHC I motif prediction | Yes (H-2); N.T. (HLA-A*0201) | [24, 33] |
| 76 kDa protein (Cpn0728) | C. pneumoniae | Surface-exposed | 1 (H-2 Db) | MHC I motif prediction | Yes | [24] |
| 43 kDa homolog protein 1 | C. pneumoniae | N.D. | 3 (H-2 Kb, H-2 Db) | MHC I motif prediction | Yes | [24] |
| 43 kDa homolog protein 2 | C. pneumoniae | N.D. | 2 (H-2 Kb) | MHC I motif prediction | Yes | [24] |
| 43 kDa homolog protein 3 | C. pneumoniae | N.D. | 1 (H-2 Kb) | MHC I motif prediction | Yes | [24] |
| 43 kDa homolog protein 4 | C. pneumoniae | N.D. | 2 (H-2 Kb, H-2 Db) | MHC I motif prediction | Yes | [24] |
| MOMP (Cpn0695) | C. pneumoniae | Outer membrane | 3 (H-2 Kb, H-2 Db, HHD Transgenic HLA-A2) | MHC I motif prediction | Yes, No (H-2); N.T. (HHD) | [24, 32, 38] |
| Pmp10 (Cpn0449) | C. pneumoniae | Outer membrane | 2 (H-2Kb) | MHC I motif prediction | Yes | [24] |
| YaeT (Cpn0300) | C. pneumoniae | Outer membrane | 1 (H-2Kb) | MHC I motif prediction | Yes | [24] |
| OmpB (Cpn0854) | C. pneumoniae | Outer membrane | 1 (H-2Kb) | MHC I motif prediction | Yes | [24] |
| IncA homolog (Cpn0585) | C. pneumoniae | Inclusion membrane | 2 (H-2 Kb, H-2 Db) | MHC I motif prediction | Yes | [24] |
| Conserved hypothetica l protein (CP0021) | C. pneumoniae | Putative secreted (heterologous T3S) | 1 (H2-M3) | MHC I motif prediction | Yes | [25] |
| SmpB (CP0421) | C. pneumoniae | Cytosolic | 1 (H2-M3) | MHC I motif prediction | Yes | [25] |
| Cap1 (CT529) | C. trachomatis | Inclusion membrane | 1 (H-2 Kd) | Expression cloning system | Yes | [34] |
| CrpA (CT442) | C. trachomatis | Inclusion membrane | 1 (H-2 Db) | Expression cloning system | Yes | [39] |
| PmpI (CT874; CTL0254) | C. trachomatis | Outer membrane | 2 (H-2 Db) | Caged MHC I tetramers | N.T. | [36] |
| Omp2 (CT443) | C. trachomatis | Outer membrane | 1 (HLA-A*0101) | Expression cloning system | Yes | [35] |
| MOMP (CT681) | C. trachomatis | Outer membrane | 5 (HLA-A2, HLA-B51) | MHC I motif prediction | Yes (HLA-A2); N.T. (HLA-B51) | [23] |
| PmpC (CT414) | C. trachomatis | Outer membrane | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |
| ClpC (CT286) | C. trachomatis | N.D. | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |
| Hypothetic al protein (CT339) | C. trachomatis | Predicted membrane | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |
| PapQ (CT601) | C. trachomatis | N.D. | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |
| Hypothetic al protein (CT610) | C. trachomatis | N.D. | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |
| NADH-ubiquinone oxidoreduct ase (CT634) | C. trachomatis | Predicted membrane | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |
| RecC (CT640) | C. trachomatis | Predicted cytosolic | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |
| YgeD (CT641) | C. trachomatis | Predicted membrane | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |
| FtsH (CT841) | C. trachomatis | Inner membrane | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |
| Hypothetic al protein (CT847) | C. trachomatis | Predicted secreted | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |
| Hypothetic al protein (CT850) | C. trachomatis | Predicted inclusion membrane | 1 (HLA-B*2705) | MHC I/proteasome cleavage motif prediction | N.T. | [37] |