Table 1.

Incidence and latency to status epilepticus in DBA and A/J mice

Measure	Dose (mg/kg)
	200	220	250	300
Incidencea
DBA
Status/testedb	1/8	3/18	11/22	9/10
%	12	17	50	90
A/J
Status/tested	5/8	11/15	8/8	2/2
%	62	73	100	100
Latencyc
DBA (min)
Mean±S.E.M.	38d	36±4	32±3	25±2
n	1	3	11	9
A/J (min)
Mean±S.E.M.	163±10	127±12	121±9	130e
n	5	11	8	2
Mortalityf
DBA
Deaths/total tested	1/9	0/18	1/21	2/12
%	11	0	5	17
A/J
Deaths/total tested	0/8	2/17	6/14	6/8
%	0	12	43	75

^aThe number of animals that experienced status relative to the number that were injected with pilocarpine is listed for the four doses of pilocarpine that were used. The incidence of status was difference for all doses (Fisher's exact test, P<0.05).

^bThe number tested was defined here as the total number, except for those mice that died in the first 60 minutes after pilocarpine administration. These mice died of a sudden tonic-clonic seizure and it could not be determined if they would have entered status, because death occurred before the 3 min used to define status (see Experimental Procedures).

^cThe latency from pilocarpine injection to the onset of status is listed for the same animals as used to evaluate incidence of status. The latency to status was statistically different for the 250 mg/kg doses, the only dose that could be compared statistically (Student's t-test, P<0.0000001).

^dLatency of the one DBA mouse that had status at the 200 mg/kg dose.

^eS.E.M. not applicable.

^fThe number of animals that had a severe tonic-clonic seizure within 60 min of pilocarpine administration is listed. These animals ceased respiration during the seizure. These animals are not included in incidence and latency calculations.