Fig. 2.
A: tension recordings from guinea pig detrusor strips showing contractile response to carbachol (1 μM). Arrow heads indicate application of carbachol. This was significantly reduced by the M3 receptor antagonist 4-DAMP (1 μM). Summary data are shown for n = 6 tissues. B: carbachol-induced contraction was not blocked by the M2 antagonist methoctramine (1 μM) but was abolished by atropine (1 μM). Summary data for methoctramine (n = 7) and atropine (n = 6) are shown in the graph. *Statistical significance.