Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A model of a novel mechanism for controlling osteoclast differentiation and function by miRNA-223 in osteoclast precursors. PU.1 induced by M-CSF activates the transcription of miRNA-223, which causes a negative control on M-CSFR expression levels. Also, induced PU.1 stimulates RANK expression, and consequently osteoclast differentiation and function are induced by M-CSF and RANKL stimulation.
