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. 2009 Feb 20;4(2):e4513. doi: 10.1371/journal.pone.0004513

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Medina-Martinez et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Lhx3 expression in Rathke's pouch of an E9.5 wild type embryo. (B) Lhx3 expression in Rathke's pouch of an E9.5 Rx-deficient embryo. (C) Lhx3 expression in the anterior pituitary of an E10.5 wild type embryo. (D) Lhx3 expression in the dysmorphic anterior pituitary of an E10.5 Rx-deficient embryo. (E) Expression of Fgf10 in the ventral hypothalamus of an E9.5 wild type embryo. (F) Expression of Fgf10 in the ventral hypothalamus of an E9.5 Rx-deficient embryo. (G) Expression of Fgf10 in the posterior pituitary of an E10.5 wild type embryo. (H) Fgf10 expression in an Rx-deficient embryo. (I) Optx2 expression in the head of an E9.5 wild type embryo. (J) Optx2 expression in the head of an E9.5 Rx−/− embryo. (K) Optx2 expression in the neuroectoderm and head surface ectoderm of an E8.5 wild type embryo. (L) Optx2 expression in the head surface ectoderm of an E8.5 Rx−/− embryo. (M) Optx2 expression in the ventral hypothalamus and optic vesicle of an E10.5 wild type embryo. (N) Lack of Optx2 expression in an E10.5 Rx−/− embryo. a – anterior pituitary, p – posterior pituitary, OV – optic vesicle, RP- Rathke's pouch, VH – ventral hypothalamus.