Table 1.
In vitro neutralization of HCV, as measured in chimpanzees: animals and antisera used
| Chimpanzee no. | Sera reacted with 64 CID50 of HCV,
strain H77 and inoculated into indicated chimpanzee
|
|
|---|---|---|
| Serum (final concentration) | Anti-HCV antibodies* detected in indicated serum | |
| 1480 | Preimmune rabbit serum (1:10) | None |
| 1479 | Normal human plasma (1:10) | None |
| 1484, 1486 | Hyperimmune rabbit anti-HVR1 (1:10) | Homologous HVR1 peptide, recombinant E1/E2 complex |
| 1475, 1442 | H79 human plasma (1:10) | Core, E1, E2, NS3, NS4, NS5 |
*
Anti-HCV antibodies directed against HVR1 (synthetic peptide with sequence of hypervariable region 1), NS3 (nonstructural 3 protein), NS4 (nonstructural 4 protein), NS5 (nonstructural 5 protein, detected by ELISA).