Figure 2.

(A) Peak current as a function of temperature activated in a heat-sensitive neuron by 400-msec step temperature changes (•). A similar relation was obtained by the quicker procedure of applying a temperature ramp (trace 1). Trace 2 shows the result of a similar temperature ramp applied to a heat-insensitive neuron. (B) Relation between current activated by a 49°C temperature step and time to half-activation of delayed current in individual neurons. •, Untreated heat-sensitive neurons; ▵, neurons exposed to BK (1 μM for 20 sec; for further details, see Fig. 3). ○, Neurons exposed to the PKC activator PMA (1 μM for 20 sec; for further details, see Fig. 4).