Figure 2.

Effects of the suppression of glucocorticoids on apomorphine-induced locomotion. Compared with animals with an intact glucocorticoid secretion (SHAM), animals in which endogenous glucocorticoids have been suppressed by adrenalectomy (ADX) showed a lower sensitivity to the locomotor effects of apomorphine, as indicated by the shift toward the right in the dose-response curve. Administration of corticosterone to ADX animals (ADX+CORT) reversed the effect of adrenalectomy on the locomotor response to 1.5 mg/kg of apomorphine. Apomorphine-induced locomotion has been cumulated over the 2 hr of testing. ∗, P < 0.05 versus SHAM or versus ADX+CORT.