Table 1.
ABIN-1 is required for regulating TNF signals in utero.
| ABIN-1 | genotype | |||||
|---|---|---|---|---|---|---|
| TNF genotype | Age | +/+ | +/− | −/− | −/− (%) | Total # |
| E15.5 pc | 12 | 32 | 17 | (27.9%) | 61 | |
| E16.5 pc | 6 | 29 | 11 | (23.9%) | 46 | |
| TNF +/+ | E18.5 pc | 11 | 16 | 11 | (28.9%) | 38 |
| newborn | 12 | 28 | 1 | (2.4%) | 41 | |
| 3–4 week | 37 | 92 | 4 | (3.0%) | 133 | |
| TNF +/− | live born | 19 | 28 | 4 | (7.8%) | 51 |
| TNF +/− | live born | 27 | 61 | 22 | (20%) | 110 |
Numbers of embryos or live born pups of the indicated genotypes at various stages of development obtained from ABIN-1+/− heterozygote intercrosses are shown. Total embryos/pups genotyped at each stage of development for each TNF genotype is indicated at right (total). The percentage of embryos that were homozygous deficient (ABIN-1−/−) among specific TNF genotypes and at specific stages of development are indicated in parentheses.