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. Author manuscript; available in PMC: 2009 Aug 12.
Published in final edited form as: Oncogene. 2008 Nov 24;28(6):910–920. doi: 10.1038/onc.2008.428

Figure 3. ER stress induces the transcription of IAP mRNA in a PERK and Akt dependent manner.

Figure 3

WT or PERK−/− fibroblasts were treated with 2µg/mL tunicamycin (A) or tunicamycin, 5µM Akt inhibitor, or both (B) as indicated. Total RNA was collected from cells and reverse transcribed with the resulting cDNA being used as a template for quantitative RT-PCR. Graphs represent the average of (A) 5, or (B) 4 experiments with error bars representing +/− SEM. For (B), P=0.011239 for cIAP1 and 0.001206 for cIAP2.