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. 2008 Dec 10;81(4):686–694. doi: 10.1093/cvr/cvn339

Figure 3.

Figure 3

Effect of NS5806 to induce the electrocardiographic and arrhythmic manifestation of Brugada syndrome in a canine right ventricular wedge preparation paced from the endocardial surface at a basic cycle length of 2 s. (A) Endocardium and epicardium action potentials and ECG were recorded before and after 5, 10, and 15 µM NS5806, as well as after 30 min of washout. About 15 µM NS5806 induce polymorphic ventricular tachycardia (PVT). Representative of n = 4. (B) About 2 mM 4-aminopyrodine (4-AP) blocked Ito and prevented 10 µM NS5806 from increasing the epicardial notch in a left ventricular wedge. Representative of n = 4.