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. 2008 Dec 10;81(4):686–694. doi: 10.1093/cvr/cvn339

Figure 6.

Figure 6

The effect of NS5806 (10 µM) at different pacing rates on the epicardial notch magnitude. (A) Representative action potentials (APs) recorded at increasing basic cycle lengths from 300 to 2000 ms from canine right (RV) and left (LV) ventricular wedge preparations. (B) The epicardial notch magnitude is plotted as percentage of phase 0 amplitude (n = 4–6). (C) Effect of isoproterenol (25 nM) to reverse the effect of NS5806 (15 µM) in a left ventricular wedge preparation. Representative of n = 3. (D) Mean data showing effect of NS5806 and NS5806+iso on various electrophysiological parameters. Results were compared by Friedman's test and Dunn's post-test.