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. Author manuscript; available in PMC: 2009 Nov 19.
Published in final edited form as: Brain Res. 2008 Sep 16;1241:18–28. doi: 10.1016/j.brainres.2008.09.011

Figure 5. Aged GFR α1+/− mice had fewer nigral TH-positive neurons than age-matched WT mice.

Figure 5

TH-immunoreactivity in the midbrain of (A) saline-treated WT mice, (B) saline-treated GFR α1+/− mice, (C) MPTP-treated WT mice, and (D) MPTP-treated GFR α1+/− mice. (E) Quantification of the average number of SN TH-positive neurons using one-way ANOVA analysis followed by Student-Nuemann-Kuels post-hoc test reveals that 26 month old GFR α1+/− mice treated with saline have significantly fewer SN TH-positive neurons than age-matched WT mice (*p<0.05). Two days after the completion of the subchronic MPTP regimen, no differences existed in the number of SN TH-positive neurons between saline-treated mice and MPTP-treated mice, regardless of genotype. Photomicrograph magnification=10x. N=8 per group. Error bars indicate SEM.