Table 2.
Category B genes that are repressed by E2 in MCF-7 cells and reversed by SP protein knockdown (SP dependent)
| Gene name |
Fold inductiona (iNSE/iNSD) |
GO biol process |
|
|---|---|---|---|
| Gene accession numbers | |||
| Category B (B0) | |||
| BI520070 | 0·75475 | No info about GO biol process | |
| NM_005919 | Mef2b | 0·755932 | Muscle development; + multiple GO terms |
| BG194714 | 0·751412 | No info about GO biol process | |
| AI748967 | 0·694444 | No info about GO biol process | |
| BI791886 | 0·685832 | No info about GO biol process | |
| BI559738 | 0·664634 | No info about GO biol process | |
| NM_020909 | Epb41l5 | 0·661818 | No info about GO biol process |
| NM_152429 | Fgfbp3 | 0·657258 | No info about GO biol process |
| AI459284 | 0·609756 | No info about GO biol process | |
| NM_018374 | Tmem106b | 0·582677 | No info about GO biol process |
| BX093288 | 0·555556 | No info about GO biol process | |
| AK091299 | 0·556604 | No info about GO biol process | |
| XM_061614 | 0·527273 | No info about GO biol process | |
| AI348944 | 0·451923 | No info about GO biol process | |
| NM_173580 | 0·736842 | No info about GO biol process | |
| AI632459 | 0·573964 | No info about GO biol process | |
| AK023938 | Lrrfip1 | 0·724638 | GO:0016481;+ multiple GO terms |
| U66581 | Gpr22 | 0·75 | G-protein coupled receptor protein signaling pathway |
| NM_020340 | Kiaa1244 | 0·795064 | GO:32012 (regulation of ARF protein signal transduction) |
| BX103217 | 0·731898 | No info about GO biol process | |
| W69651 | 0·56 | No info about GO biol process | |
| NM_173580 | 0·736842 | No info about GO biol process | |
| Category B (B+) | |||
| NM_004799 | Zfyve9 | 0·765625 | Endocytosis; + multiple GO terms |
| Category B(B-) | |||
| AA323614 | 0·799242 | No info about GO biol process | |
| NM_024056 | Tmem106c | 0·796373 | No info about GO biol process |
| NM_018186 | C1orf112 | 0·790563 | No info about GO biol process |
| NM_014793 | Lcmt2 | 0·786538 | No info about GO biol process |
| NM_014920 | Ick | 0·768975 | Protein amino acid phosphorylation |
| NM_001310 | Crebl2 | 0·767041 | Signal transduction; transcription |
| NM_022746 | Mosc1 | 0·765499 | No info about GO biol process |
| BM723321 | 0·762322 | No info about GO biol process | |
| NM_152524 | Sgol2 | 0·758025 | GO:7049 (cell cycle);+ multiple GO terms |
| NM_025004 | Ccdc15 | 0·754331 | No info about GO biol process |
| NM_002774 | Klk6 | 0·752992 | Regulation of cell differentiation; + multiple GO terms |
| NM_016076 | Fam152a | 0·741884 | No info about GO biol process |
| BG740877 | 0·741463 | No info about GO biol process | |
| NM_024430 | Pstpip2 | 0·736111 | No info about GO biol process |
| AA046178 | 0·731949 | No info about GO biol process | |
| AA809349 | 0·732218 | No info about GO biol process | |
| AK026856 | 0·729258 | No info about GO biol process | |
| CB962212 | 0·728643 | No info about GO biol process | |
| NM_003400 | Xpo1 | 0·720289 | GO:6406 (mRNA export from nucleus);+ multiple GO terms |
| NM_014240 | Limd1 | 0·719298 | Development; + multiple GO terms |
| NM_016551 | Tm7sf3 | 0·718053 | No info about GO biol process |
| NM_006479 | Rad51ap1 | 0·71855 | GO:6281 (DNA repair);+ multiple GO terms |
| NM_022374 | Atl2 | 0·712202 | Immune response |
| NM_012287 | Acap2 | 0·703775 | GO:43087 (regulation of GTPase activity) |
| NM_005226 | S1pr3 | 0·703278 | Morphogenesis; + multiple GO terms |
| AI979035 | 0·698925 | No info about GO biol process | |
| NM_016203 | Prkag2 | 0·696429 | Cholesterol biosynthesis; + multiple GO terms |
| AA261924 | 0·695868 | No info about GO biol process | |
| NM_001278 | Chuk | 0·687229 | Immune response; + multiple GO terms |
| AA653936 | 0·686189 | No info about GO biol process | |
| NM_020132 | Agpat3 | 0·682759 | Metabolism; + multiple GO terms |
| NM_007027 | Topbp1 | 0·677027 | DNA metabolism; + multiple GO terms |
| BQ013447 | 0·675 | No info about GO biol process | |
| BI754506 | 0·670455 | No info about GO biol process | |
| NM_032876 | 0·668553 | No info about GO biol process | |
| NM_153826 | Capg | 0·6639 | Complement activation, classical pathway |
| NM_016824 | Add3 | 0·664298 | Apoptosis; + multiple GO terms |
| NM_016359 | Nusap1 | 0·663537 | G0:0000281;+ multiple GO terms |
| BG285682 | 0·65847 | No info about GO biol process | |
| NM_172240 | Wdr51b | 0·652372 | No info about GO biol process |
| N40495 | 0·647321 | No info about GO biol process | |
| NM_003415 | Znf268 | 0·646 | Regulation of transcription, DNA dependent |
| NM_139279 |
Mcfd2; Lman1; Mcfd2 |
0·637809 | GO:6888 (ER to Golgi vesicle-mediated transport);+ multiple GO terms |
| NM_032525 | Tubb6 | 0·633021 | Microtubule-based movement |
| AK091460 | Znf813 | 0·626354 | No info about GO biol process |
| NM_017709 | Fam46c | 0·624658 | No info about GO biol process |
| NM_138635 | H2afv | 0·621495 | GO:6334 (nucleosome assembly);+ multiple GO terms |
| AK056236 | 0·621074 | No info about GO biol process | |
| NM_173556 | Ccdc83 | 0·605682 | No info about GO biol process |
| NM_002128 | Hmgb1 | 0·59 | DNA unwinding; + multiple GO terms |
| NM_020927 | Vat1l | 0·582734 | No info about GO biol process |
| NM_016516 | Vps54 | 0·564955 | GO:15031 (protein transport);+ multiple GO terms |
| NM_018836 | Ajap1 | 0·533835 | No info about GO biol process |
| NM_019087 | Arl15 | 0·515924 | No info about GO biol process |
| AI218135 | 0·647059 | No info about GO biol process | |
| AI742318 | 0·314286 | No info about GO biol process | |
| BU069371 | 0·224138 | No info about GO biol process | |
| NM_001701 | Baat | 0·772727 | Bile acid metabolism; + multiple GO terms |
| NM_007023 | Rapgef4 | 0·675676 | Exocytosis; + multiple GO terms |
| AI480013 | 0·52381 | No info about GO biol process | |
a
MCF-7 cells transfected with iNS (nonspecific oligonucleotide) and treated with either 10 nM E2 (iNSE) or DMSO (iNSD).