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. 2009 Feb 13;106(9):3537–3542. doi: 10.1073/pnas.0813224106

Fig. 1.

Fig. 1.

cAMP dynamics in OSN. Normalized kinetics of fluorescence emission intensities (480 nm/545 nm) recorded in cilia-dendrite, soma, and axon termini-growth cone in OSN transfected with the PKA-based sensor and challenged with the following: (A) forskolin (Frsk,3 μM) and subsequently with IBMX (100 μM); (C) IBMX (100 μM) and subsequently with forskolin (25 μM); (B) and (D) time for half-maximal response (t1/2) for cells treated with forskolin, (B) (dendrite-soma P = 0.004**, cone-soma P = 0.002**) and (D) IBMX (dendrite-soma P = 0.04*, cone-soma P = 0.007**); bars, SEM. The regions of interest (ROIs) were drawn on the distal part of the axon and dendrite and on the soma. The cilia were included in the dendrite ROI but were too thin to be clearly identified at the magnification used. Green line, axon termini-growth cone; pink line, soma; blue line, cilia-dendrite.