Fig. 7.

Oxidation reduces ASIC1a current amplitude. (A and B) Representative traces from Xenopus oocytes injected with WT (A) or LLAA (B) ASIC1a and treated without (control) or with 20 mM H₂O₂ for 6 min. (C) Time course of current amplitude after 20 mM H₂O₂ addition (n = 16–22). Asterisks indicate P < 0.05. (D) Representative traces showing effect of intracellular injection of ≈1.4 pl of H₂O₂. (E) Quantification of effect of intracellular H₂O₂ on current (n = 8 WT and n = 9 LLAA experiments). Asterisk indicates P = 0.035, unpaired t test.