Table 2.
A: Stability as Concentrated Solutions in 0.1 M acetic acid at 4°C | |||||||
---|---|---|---|---|---|---|---|
Chlorpromazine | Olanzapine | ||||||
Time (weeks) | Concentration (mg/ml) | SD | R.S.D. (%) | Time (weeks) | Concentration (mg/ml) | SD | RSD. (%) |
0 | 20.5 | 0.34 | 1.66 | 0 | 12.3 | 0.20 | 1.60 |
1 | 19.7 | 0.22 | 1.14 | 1 | 12.4 | 0.05 | 0.41 |
2 | 19.8 | 0.60 | 3.05 | 2 | 12.1 | 0.05 | 0.38 |
4 | 19.6 | 0.01 | 6.54 | 4 | 12.2 | 0.13 | 1.09 |
B: Stability of Dilutions in Rodent Drinking Water | |||||||
---|---|---|---|---|---|---|---|
Chlorpromazine (Tap water) | Chlorpromazine (distilled/deionized Water) | ||||||
Time (hours) | Concentration (µg/ml) | SD | R.S.D. (%) | Time (hours) | Concentration (µg/ml) | SD | RSD. (%) |
0 | 87.4 | 2.33 | 2.67 | 0 | 87.6 | 1.14 | 1.30 |
6 | 87.1 | 2.75 | 3.15 | 6 | 86.2 | 0.53 | 0.61 |
24 | 88.1 | 1.53 | 1.74 | 24 | 87.6 | 0.76 | 0.86 |
48 | 87.2 | 1.89 | 2.17 | 48 | 87.8 | 0.88 | 1.01 |
72 | 85.6 | 2.22 | 2.60 | 72 | 86.0 | 1.17 | 1.36 |
96 | 81.8 | 2.47 | 3.02 | 96 | 81.7 | 0.26 | 0.32 |
Olanzapine (Tap water) | Olanzapine(distilled/deionized Water) | ||||||
0 | 103.6 | 1.77 | 1.71 | 0 | 106.1 | 0.44 | 0.41 |
6 | 102.8 | 0.74 | 0.72 | 6 | 104.9 | 1.29 | 1.23 |
24 | 108.5 | 3.03 | 2.79 | 24 | 106.9 | 2.36 | 2.21 |
48 | 105.0 | 0.62 | 0.59 | 48 | 106.8 | 1.76 | 1.65 |
72 | 102.3 | 0.70 | 0.68 | 72 | 101.2 | 0.15 | 0.15 |
96 | 98.8 | 1.21 | 1.23 | 96 | 101.6 | 0.95 | 0.94 |
N=3 samples per determination; SD= Standard Deviation; RSD= relative standard deviation