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. Author manuscript; available in PMC: 2009 Oct 28.
Published in final edited form as: Neuroscience. 2008 Aug 27;156(4):1005–1016. doi: 10.1016/j.neuroscience.2008.08.030

Table 2.

Stability of Chlorpromazine and Olanzapine

A: Stability as Concentrated Solutions in 0.1 M acetic acid at 4°C
Chlorpromazine Olanzapine
Time (weeks) Concentration (mg/ml) SD R.S.D. (%) Time (weeks) Concentration (mg/ml) SD RSD. (%)
0 20.5 0.34 1.66 0 12.3 0.20 1.60
1 19.7 0.22 1.14 1 12.4 0.05 0.41
2 19.8 0.60 3.05 2 12.1 0.05 0.38
4 19.6 0.01 6.54 4 12.2 0.13 1.09
B: Stability of Dilutions in Rodent Drinking Water
Chlorpromazine (Tap water) Chlorpromazine (distilled/deionized Water)
Time (hours) Concentration (µg/ml) SD R.S.D. (%) Time (hours) Concentration (µg/ml) SD RSD. (%)
0 87.4 2.33 2.67 0 87.6 1.14 1.30
6 87.1 2.75 3.15 6 86.2 0.53 0.61
24 88.1 1.53 1.74 24 87.6 0.76 0.86
48 87.2 1.89 2.17 48 87.8 0.88 1.01
72 85.6 2.22 2.60 72 86.0 1.17 1.36
96 81.8 2.47 3.02 96 81.7 0.26 0.32
Olanzapine (Tap water) Olanzapine(distilled/deionized Water)
0 103.6 1.77 1.71 0 106.1 0.44 0.41
6 102.8 0.74 0.72 6 104.9 1.29 1.23
24 108.5 3.03 2.79 24 106.9 2.36 2.21
48 105.0 0.62 0.59 48 106.8 1.76 1.65
72 102.3 0.70 0.68 72 101.2 0.15 0.15
96 98.8 1.21 1.23 96 101.6 0.95 0.94

N=3 samples per determination; SD= Standard Deviation; RSD= relative standard deviation