Table 1.

Identification of changes in the abundance of proteins in siRNA2-treated Caco-2 cells

Protein description	SWISS-PROT accession no.	General function	Observation	Ref
Up-regulation in cells treated with siRNA2
Isocitrate dehydrogenase	P48735	Metabolism and mitochondria	Strong expression in primary colon tumor tissues	Mazurek et al. (2000)
Proliferation-associated protein 2 GA	P14555	Signal transduction	Increased expression in colorectal tumors and in proliferative Caco-2 cells	Santegoets et al. (2007), Turck et al. (2004)
Heterogeneous nuclear ribonucleoprotein K	P61978	Transcription factor and DNA binding	Overexpressed in colorectal cancer	Carpenter et al. (2006)
Lamin A	P02545	Signal transduction/structural protein	Promoted tumour invasiveness in colorectal cancer	Willis et al. (2008)
Down-regulation in cells treated with siRNA2
Pro-Meprin A subunit alpha	Q16819	Metabolism and mitochondria	Increased expression during Caco-2 cell differentiation	Rosmann et al. (2002)
Creatine kinase B	P12277	Metabolism and mitochondria	Decreased expression level in colon tumors	Balasubramani et al. (2006)
			Increased expression during Caco-2 cell differentiation
Glutathione S-transferase	P09210	Signal transduction	Increased expression of GST1 during Caco-2 cell differentiation	Stierum et al. (2003), Pshezhetsky et al. (2007)
Galectin-3	P17931	Signal transduction	Increased expression during Caco-2 cell differentiation	Pshezhetsky et al. (2007)

Proteins are shown that have been reported to be involved in Caco-2 cell differentiation or in colorectal cancer.