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Evolutionary conservation of deadenylation by GU-rich sequences and CELF proteins. (A). In Xenopus, after fertilization, EDEN-BP bound to EDEN-containing mRNAs causes deadenylation and subsequent translational repression. (B). In mammalian cells, CUGBP1 binds to GREs within the 3′ UTR of specific transcripts and promotes their deadenylation and subsequent decay.
