Skip to main content
. Author manuscript; available in PMC: 2009 Dec 10.
Published in final edited form as: Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):222–232. doi: 10.1016/j.resp.2008.05.014

Figure 3. Exogenous 5-HT stimulates breathing in mice lacking central 5-HT neurons.

Figure 3

Immunocytochemical staining for 5-HT in the dorsal raphé and caudal raphé of wild type (A & B) and Lmx1bf/f/p (knockout) mice (C & D). E) Plethysmography tracings from WT (blue), Lmx1bf/f/p (red) and Lmx1bf/f/p mice with intracerebroventricular (ICV) 5-HT (green) at baseline (control) and breathing 7% CO2. F) ICV 5-HT stimulates ventilation at rest and while breathing 5 and 7% CO2. A-D is adapted from Zhao et al., 2006, and E & F from Hodges et al., 2008.