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. Author manuscript; available in PMC: 2009 Dec 10.
Published in final edited form as: Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):222–232. doi: 10.1016/j.resp.2008.05.014

Figure 4. Trophic effects of 5-HT on cortical and brainstem networks in monoamine oxidase A knockout (MAOA-KO) mice.

Figure 4

A) Camera lucida drawings of biocytin-stained phrenic motor neurons from wild type (C3) and MAOA-KO (Tg8) mice. Note that DOI in the wild type increases, whereas SR46349B in MAOA-KO mice decreases, dendritic morphology. B) Phrenic nerve recordings (raw and integrated data) from brainstem-spinal cord preparations. Frequency responses to 5-HT in MAOA-KO mice are completely blunted, likely due to extremely high levels of endogenous 5-HT. A & B were adapted from Bou-Flores et al., 2000.