Table 2. The odds for moderate to severe impact on specific GI symptoms with frequent (≥8 days/month) trouble falling asleep, trouble staying asleep, nighttime awakenings, relative to less frequent (<8 days/month) sleep disturbance characteristics.

GI Symptom	Trouble Falling Asleep	Wake >1 per night	Trouble staying Asleep
Fullness	1.36 (0.72, 2.60)	0.48 (0.21, 1.07)	2.92 (1.29, 6.64)
Bloating	0.81 (0.54, 1.24)	1.11 (0.71, 1.74)	1.43 (0.91, 2.26)
Pain	1.29 (0.87, 1.93)	2.06 (1.35, 3.16)	1.02 (0.66, 1.57)
Food staying in the stomach	1.62 (0.94, 2.79)	1.19 (0.64, 2.23)	1.37 (0.73, 2.57)
Nausea	1.40 (0.96, 2.03)	1.82 (1.22, 2.71)	0.94 (0.62, 1.41)
Vomiting	1.26 (0.85, 1.88)	1.28 (0.85, 1.93)	1.17 (0.76, 1.80)
Dysphagia	1.23 (0.86, 1.77)	1.49 (1.04, 2.14)	1.10 (0.75, 1.61)
Acid regurgitation	1.11 (0.72, 1.69)	1.45 (0.92, 2.28)	1.12 (0.71, 1.79)
Heartburn	1.20 (0.78, 1.85)	1.35 (0.88, 2.07)	0.89 (0.56, 1.40)
Diarrhea	1.20 (0.79, 1.84)	2.17 (1.43, 3.29)	0.86 (0.56, 1.33)
Urgency	1.55 (1.00, 2.40)	2.23 (1.43, 3.49)	0.85 (0.54, 1.35)
Loose stools	1.11 (0.73, 1.69)	2.29 (1.48, 3.54)	0.99 (0.64, 1.55)
Constipation	0.88 (0.49, 1.57)	1.62 (0.91, 2.90)	1.06 (0.59, 1.93)
Blockage at evacuation	0.61 (0.35, 1.08)	1.88 (1.01, 3.49)	1.63 (0.90, 2.96)
Hard stools	0.71 (0.45, 1.13)	1.43 (0.90, 2.27)	1.48 (0.92, 2.37)
Fecal incontinence	1.10 (0.63, 1.93)	1.41 (0.85, 2.34)	0.91 (0.52, 1.59)

Odds ratios (95% C.I.) adjusted for age, gender, smoking status, alcohol use and SF-12 mental health status score.

GI symptoms with presence reported as often or very often (>3 on Likert scale) were considered moderate to severe impact.