Figure 3.

Body weight gain in nicotine-abstinent rats treated chronically with CRF-BP ligand inhibitor. Mean ± SEM body weight gain is exhibited over two 14-day periods of exposure to saline or nicotine (Nicotine Infusion) and following exposure to saline or nicotine (Nicotine Withdrawal). CRF-BP ligand inhibitor (0 or 25 μg/day i.c.v.) was administered chronically over the first 7 days of abstinence [r/h CRF (6-33) Infusion] to both saline-control and nicotine withdrawn groups (n = 6 per group). (Upper) Daily changes in body weight relative to pretreatment baseline weight and (Lower) cumulative weight gain over experimental days 14–28. ∗, P < 0.05