Table 1.

Central cardiovascular effects of CRF receptor agonist and CRF-BP ligand inhibitor peptides

Treatment	Δ MAP, mmHg	ΔHR, beats per min
Vehicle	−1.2  ±  0.4	0
oCRF (1-41)
10 μg	+17.2  ±  3.9	+20.6  ±  2.8
25 μg	+26.9  ±  1.4	+42.0  ±  3.4
oCRF (6-33)
25 μg	+0.3  ±  0.1	0
50 μg	+1.7  ±  0.6	0
r/h CRF (6-33)
25 μg	−4.9  ±  0.9	−17.9  ±  2.1
50 μg	−7.2  ±  0.8	−34.4  ±  4.0

Effect of i.c.v. injection of CRF agonist [oCRF (1-41)], a control peptide [oCRF (6-33)], CRF-BP ligand inhibitor [r/h CRF (6-33)], or vehicle on mean arterial pressure (MAP) and heart rate (HR) in conscious, freely moving rats.