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. Author manuscript; available in PMC: 2009 Feb 15.
Published in final edited form as: Nature. 2008 Mar 26;452(7187):591–597. doi: 10.1038/nature06765

Figure 3. CNV suppression by targeted siRNAs is mediated by TLR3.

Figure 3

a, hVegfa siRNA and Vegfr1 siRNA suppressed CNV in Tlr3+/+ but not Tlr3−/− mice. b, Vegfr1-siRNA–chol suppressed CNV in Tlr3+/+ but not Tlr3−/− mice. n = 5–6. c, hVegfa siRNA and Vegfr1 siRNA, whose anti-sense (as) strands were modified with 5′-methoxy (CH3O) substitution, preventing incorporation into RISC, suppressed CNV in Tlr3+/+ but not Tlr3−/− mice. n = 9–14. d, siRNAs targeting mouse (m) or human (h) Vegfa reduced CNV in Tlr3+/+ but not in Tlr3−/− mice. mVegfa-siRNA–chol and hVegfa-siRNA–chol suppressed CNV in Tlr3+/+ mice; however, mVegfa-siRNA–chol but not hVegfa-siRNA–chol suppressed CNV in Tlr3−/− mice. n = 8–10. siRNAs were at 1 μg; asterisk, P < 0.05 compared to vehicle (siRNA buffer). All error bars indicate mean ± s.e.m.