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. Author manuscript; available in PMC: 2010 Feb 1.

Published in final edited form as: Bioorg Med Chem Lett. 2008 Dec 10;19(3):792–796. doi: 10.1016/j.bmcl.2008.12.031

Table 3.

Stability of vidarabine and its prodrugs in biological homogenates and plasma from rat

Promoiety (Compound)	T_1/2 (hours)
	Intestinal homogenate	Liver homogenate	Plasma
Vidarabine (1)	0.05	0.25	0.43
D-ile (7c)	7.90	0.31	1.61
L-ile (7k)	0.58	0.06	3.58
D-leu (7b)	0.04	0.06	na^b
L-leu (7j)	0.03	0.05	na^b
D-phe (7d)	0.59	0.10	na^b
L-phe (7l)	0.27	<0.017	na^b
L-val (7j)	0.30	0.03	0.13
D-val (7a)	St^a	0.46	10.26
P-L val^c (10a)	18.32	5.91	0.35
P-D val^c (10b)	St^a	St^a	0.30

^a

St means stable.

^b

na means not analyzed.

^c

Phosphoramidate prodrug.