Table 3.
Multivariate ANOVA modeling of exercise training—induced changes in ISI, and insulin and glucose AUC by CRP -732A/G genotype
| Dependent and independent variables |
Model 1 (bivariate) |
Model 2 (adjusted) |
Model 3 (adjusted) |
Model 4 (adjusted) |
|---|---|---|---|---|
| R2( P) | R2( P) | R2( P) | R2( P) | |
| Change in glucose AUC (%) |
4 | 12.0 | 20.4 | 24.3 |
| CRP -732A/G genotype | (.15) | (.10) | (.06) | (.04)a |
| Glucose AUC (baseline) | (.94) | (.58) | (.78) | |
| CRP (baseline) | (.05)a | (.04)a | (.14) | |
| Change in insulin AUC (%) | 6 | 15.9 | 20.3 | 29.2 |
| CRP -732A/G genotype | (.07) | (.09) | (.10) | (.08) |
| Insulin AUC (baseline) | (.07) | (.11) | (.99) | |
| CRP (baseline) | (.66) | (.49) | (.56) | |
| Change in ISI (%) | 13 | 26.1 | 32.6 | 35.3 |
| CRP -732A/G genotype | (<.01)a | (.03)a | (.02)a | (.02)a |
| ISI (baseline) | (.02)a | (.02)a | (.32) | |
| CRP (baseline) | (.43) | (.30) | (.39) |
Model 1 is bivariate with CRP -732A/G genotype as independent variable; model 2 is multivariate adjusted for baseline values of the dependent variable and CRP levels; model 3 is also adjusted for age, sex, and ethnicity; and model 4 is additionally adjusted for training-related changes in body weight and percentage of total body fat.
a
Statistically significant effect at an α level of less than .05.