Table 2.
rs1799990 and three novel candidate SNPs in samples from Papua New Guinea
|
Resistance to kuru despite exposure |
Early-onset and late-onset kuru |
Combined p value* | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Elderly women exposed to kuru | Healthy young Fore | Model | p value | Young kuru (age <25 years) | Older kuru (age >25 years) | Model | p value (kuru incubation) | ||
| rs1799990 | 16/86/23 | 112/287/163 | G | 0·001 | 16/18/25 | 9/71/12 | G | 9·1×10−8 | 2·2×10−9 |
| rs6116492 | 80/37/2 | 393/151/18 | A | 0·848 | 47/11/0 | 57/20/0 | A | 0·44 | .. |
| rs1460163 | 30/77/16 | 140/144/40 | R | 2·5×10−4 | 23/29/5 | 26/42/23 | A | 0·017 | 5·7×10−5 |
| rs6794719 | 5/47/63 | 26/118/136 | A | 0·12 | 4/25/27 | 7/33/47 | A | 0·687 | .. |
Genetic models: A=allelic; G=genotypic; R=recessive.
*
Fisher's method.