Figure 3.
Compounds 2c (yellow) and 2d (purple) docked into the active site of μ-calpain. Notice that the diphenyl group of 2c unlike that of 2d does not effectively access the S3 pocket. The S,S-diastereomers were studied.
Compounds 2c (yellow) and 2d (purple) docked into the active site of μ-calpain. Notice that the diphenyl group of 2c unlike that of 2d does not effectively access the S3 pocket. The S,S-diastereomers were studied.