TABLE 2.
UNIVARIATE FACTORS ASSOCIATED WITH CHANGE IN ASTHMA SYMPTOMS DURING THE COLD
| Factor | P Value |
|---|---|
| Change in peak expiratory flow | 0.002 |
| Baseline FEV1, % predicted | 0.796 |
| Baseline methacholine PC20 | 0.772 |
| Rhinovirus detection, yes/no | 0.149 |
| Peak cold symptoms | 0.010 |
| Change in cold symptoms | 0.095 |
| Precold ICS use | 0.005 |
| Peak nasal lavage neutrophils | <0.001 |
| Change in nasal lavage neutrophils | 0.019 |
| Peak sputum neutrophils | 0.337 |
| Change in sputum neutrophils | 0.160 |
| P2X7 pore activity | 0.012 |
Definition of abbreviations: ICS = inhaled corticosteroids; methacholine PC20 = provocative concentration of methacholine causing a 20% fall in FEV1.
Univariate analysis by the least-squares or logistic method was applied for the preceding factors after data transformation to the normal distribution.