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. 2009 Feb;30(1):19–34.

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The contents of articles or advertisements in The Clinical Biochemist – Reviews are not to be construed as official statements, evaluations or endorsements by the AACB, its official bodies or its agents. Statements of opinion in AACB publications are those of the contributors. Print Post Approved - PP255003/01665. Copyright © 2005 The Australasian Association of Clinical Biochemists Inc. No literary matter in The Clinical Biochemist – Reviews is to be reproduced, stored in a retrieval system or transmitted in any form by electronic or mechanical means, photocopying or recording, without permission. Requests to do so should be addressed to the Editor. ISSN 0159 – 8090

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Principle of stable isotope dilution. Four nmoles of internal standard are added at the beginning of the assay, fixing the internal standard:analyte ratio (1:2 in this case). Analyte and internal standard are lost in subsequent processing steps but the ratio remains the same. LC-MS = liquid chromatography-mass spectrometry.