Table 1.

Maximum likelihood estimates of mean (µ), standard deviation (σ), heritability (h²), standardized β coefficients and their standard errors, associated P-values, and proportion of total variance explained by covariates are given for PON1 activity levels for three substrates.

Parameter	PON1-para	PON1-aryl	PON1-lact
µ	166.1±3.7	82.3±1.1	9.59±0.13
σ	63.1±1.6	18.6±0.5	2.35±0.06
h2, %	97.9±1.8	85.2±5.6	78.4±5.6
βage	−0.095±0.029*	−0.184±0.028***	−0.198±0.029***
βcontraceptive	0.029±0.026	0.077±0.025*	0.080±0.025*
βsmoking	−0.089±0.027*	−0.102±0.026**	−0.097±0.027**
βapoAI	0.046±0.036	0.157±0.033***	0.155±0.034***
βapoAII	0.244±0.036***	0.314±0.035***	0.236±0.036***
βtriglycerides	−0.001±0.042	0.084±0.040*	0.002±0.041
βnonHDLC	0.064±0.036	0.114±0.034**	0.169±0.035***
Covariate Effects, %	5.2	25.1	21.2

PON activity units are nmol/min/mL for PON1-para and µmol/min/mL for PON1-aryl and PON1-lact. Standardized β coefficients were estimated in separate models in which traits and covariates were standardized (z-score); key to P-values:

^*P<0.05;

^**P<0.001;

^***P<0.00001.