Table 3.
Chromosomal (Chr) locations and LOD scores are indicated for primary and secondary multipoint LOD score peaks from analyses of covariate-adjusted and normalized PON1 activities for three substrates.
| Primary QTL | Secondary QTL | ||||
|---|---|---|---|---|---|
| Substrate | Model | Chr (cM) | LOD | Chr (cM) | LOD |
| PON1-para | 1 | 7q (105) | 23.0 | 3p (70) | 2.9 |
| PON1-para | 2 | 7q (104) | 38.1 | 3p (59) | 3.4 |
| PON1-para | 3 | 7q (106) | 10.7 | 14q (43) | 2.2 |
| PON1-aryl | 1 | 7q (104) | 8.9 | 1p (33) | 1.9 |
| PON1-aryl | 2 | 7q (105) | 20.1 | 1p (32) | 2.8 |
| PON1-aryl | 3 | 7q (106) | 15.7 | 1p (32) | 2.7 |
| PON1-lact | 1 | 7q (105) | 16.5 | 14q (32) | 1.9 |
| PON1-lact | 2 | 7q (105) | 28.3 | 14q (48) | 3.4 |
| PON1-lact | 3 | 7q (107) | 18.5 | 14q (48) | 2.5 |
Model 1 - demographic covariates only; Model 2 - Model 1 plus metabolic covariates; Model 3 - Model 2 plus Q192R and L55M genotype information. LOD scores in bold are significant at the genome-wide level.