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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Heredity (Edinb). 2008 Oct 29;102(2):147–154. doi: 10.1038/hdy.2008.110

Table 4.

Proportions (%) of phenotypic variance for PON1-para, PON1-aryl, and PON1-lact associated with covariates and genes.

PON1-para PON1-aryl PON1-lact
Environmental Covariates  5 25 21
  Demographic     1     6     5
  Metabolic     4   19   16
Genetic 92 65 67
  QTL-chr7   71   39   47
  QTL-chr3     8     4     2
  QTL-chr14     4   12   13
  Residual     9   10     5
Unexplained  3 10 12

Demographic covariates included age, contraceptive usage, and smoking status; metabolic covariates included concentrations of apoAI, apoAII, triglycerides, and non-HDLC. QTL effect sizes are subject to a strong upward bias and, therefore, the residual genetic component is likely to be underestimated.