TABLE 3.

INCREMENTS IN MEDIATOR RELEASE FROM NASAL AND BRONCHIAL AIRWAY EPITHELIAL CELLS STIMULATED WITH IL-1β AND TNF-α

	Median (IQR) % Increase in Mediator Release in Response to Cytokine Stimulation
Mediator	Nasal AEC	Bronchial AEC	P Value*
IL-8	245.9 (335.0)	195.5 (246.4)	0.397
IL-6	178.8 (215.6)	162.7 (192.0)	0.765
G-CSF	397.3 (1,086.5)	656.4 (905.5)	0.695
MCP-1	392.2 (697.0)	395.2 (509.6)	0.694
RANTES	392.9 (991.4)	438.1 (869.9)	0.837
VEGF	12.0 (44.5)	0.0 (32.9)	0.337
MMP-9	37.9 (59.5)	32.0 (53.8)	0.961
TIMP-1	2.6 (26.8)	−9.8 (28.2)	0.128

Definition of abbreviations: AEC, airway epithelial cells; G-CSF, granulocyte colony-stimulating factor; IQR, interquartile range; MCP-1, monocyte chemoattarctant protein-1; MMP-9, matrix metalloproteinase-9; RANTES, regulated on avtivation, normal T cells expressed and secreted; TIMP-1, tissue inhibitor of metalloproteinase-1; VEGF, vascular endothelial growth factor.

^*Percentage changes from paired nasal and bronchial AEC cultures were compared using Wilcoxon matched pairs test (n = 35, with two replicates).