TABLE 1.
BASELINE CHARACTERISTICS OF PATIENTS WITH TUBERCULOSIS-ASSOCIATED IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME AND COMPARATOR NON-IRIS AND UNTREATED HIV+TB GROUPS
| TB–IRIS | Non-IRIS | Untreated HIV+TB | |
|---|---|---|---|
| N | 35 | 29 | 31 |
| Median age, yr (IQR) | 31.4 (25.8–36.2) | 35.6 (30.3–41.0) | 28 (25–36)* |
| Baseline CD4+ cell count, cells/μl (IQR) | 51 (29–106) | 45 (23–122) | 195 (111–331)† |
| TB treatment before cART, d | 55 (30–82) | 78 (38–132)‡ | N/A |
| Days of cART to IRIS or to sample | 14 (8–21) | 14 (14, 15) | N/A |
| Females, n (%) | 23 (66) | 19 (66) | 18 (58) |
| Previous TB, n (%) | 12 (34) | 4 (14) | 7 (23) |
| TB disease form, n (%) | |||
| Pulmonary or pleural | 21 (60) | 22 (76) | 31 (100) |
| Disseminated | 11 (31) | 4 (14) | |
| Lymphadenopathic | 3 (9) | 3 (10) | |
| Smear or culture confirmed? | 19 (54) | 16 (55) | 30 (97)§ |
Definition of abbreviations: cART = combination antiretroviral therapy; N/A = not applicable; TB = tuberculosis; TB–IRIS = tuberculosis-associated immune reconstitution inflammatory syndrome.
*
Significantly lower than non-IRIS: P = 0.018.
†
Significantly higher than TB–IRIS and non-IRIS: P < 0.0001.
‡
Significantly more than TB–IRIS: P = 0.011.
§
Significantly more than TB–IRIS and non-IRIS: P < 0.0001.