TABLE 2.
CLINICAL CHARACTERISTICS OF TB–IRIS THAT AROSE DURING LONGITUDINAL FOLLOW-UP OF HIV-INFECTED PATIENTS WITH TUBERCULOSIS WHO RECEIVED COMBINATION ANTIRETROVIRAL THERAPY
| Patient no. | Sex | Age (yr) | CD4+ Cell Count Nadir (cells/μl) | Presenting Form of TB | Days of cART to TB–IRIS | Presentation of IRIS |
|---|---|---|---|---|---|---|
| B13 | F | 38 | 92 | Culture-positive PTB | 13 | Developed new right cervical lymphadenopathy |
| B20 | M | 36 | 92 | Clinical PTB | 28 | Transient worsening of pulmonary symptoms |
| B28 | M | 46 | 30 | Disseminated | 7 | Worsening pulmonary infiltrate, hepatomegaly, and tachycardia. |
| B31 | F | 37 | 71 | Culture-positive disseminated | 13 | Hepatic enlargement and cholestatic LFT derangement: liver biopsy showed necrotizing granulomas |
| B30 | F | 42 | 42 | Clinical PTB | 14 | Anemia and new cervical lymphadenopathy |
| B33 | M | 28 | 5 | Culture-positive pleural | 14 | Worsening pulmonary infiltrate |
| B34 | M | 30 | 13 | Culture-positive PTB | 15 | Pleurisy, cough, and high fever. |
| B38 | M | 37 | 10 | Disseminated, smear positive | 7 | Fever, confusion, and lymphocytic meningitis |
| B49 | F | 36 | 113 | Disseminated, smear positive | 12 | New headache and fever, found to have meningitis and a tuberculoma |
| B52 | F | 20 | 48 | Disseminated | 28 | New bilateral cervical lymphadenopathy |
Definition of abbreviations: cART = combination antiretroviral therapy; F = female; LFT = liver function test; M = male; PTB = pulmonary tuberculosis; TB–IRIS = tuberculosis-associated immune reconstitution inflammatory syndrome.