TABLE 2.

GENES FROM CLUSTER 1 (EARLY HYPOXIA-INDUCED INCREASES IN EXPRESSION) THE PROMOTERS OF WHICH CONTAIN PUTATIVE CREB BINDING SITES

Gene Name	Gene Symbol	Hypoxia	CREB	HIF-1/HRE
A kinase (PRKA) anchor protein (gravin) 12	AKAP12	No	No	No
Activating transcription factor 3	ATF3	Yes	Yes	No
Arginine vasopressin-induced 1	AVPI1	No	Yes	No
Brain-derived neurotrophic factor	BDNF	Yes	Yes	No
Cyclin-dependent kinase inhibitor 1A (P21)	CDKN1A	Yes	Yes	Yes
Cholesterol 25-hydroxylase	CH25H	No	No	No
DNA damage–inducible transcript 4	DDIT4	Yes	No	Yes
Endothelin-1	EDN1	Yes	No	Yes
Eukaryotic translation initiation factor 2–3	EIF2S3X	No	No	No
Eukaryotic translation initiation factor 4A	EIF4A1	No	No	No
FMS-like tyrosine kinase 1 (VEGFR-1)	VEGFR1	Yes	Yes	Yes
Follistatin	FST	No	Yes	No
V-MAF musculoaponeurotic fibrosarcoma F	MAFF	Yes	No	No
Myocardin	MYOCD	Yes	No	No
N-MYC downstream-regulated gene 1	NDRG1	Yes	No	Yes
Plasminogen activator, tissue (tPA)	PLAT	No	Yes	No
Polo-like kinase 2 (Drosophila)	PLK2	No	No	No
Riken CDNA 1300003H02 gene	QSCN6	No	No	No
T cell lymphoma invasion and metastasis 1	TIAM1	No	No	No
Tumor necrosis factor receptor member 12A	TNFRSF12A	No	No	No
Tubulin, alpha 8 (PEX26)	TUBA8	No	No	No

Definition of abbreviations: CREB = cAMP response element binding; HIF = hypoxia-inducible factor; HRE = hypoxia response element; VEGFR = vascular endothelial growth factor receptor.

The column headed hypoxia indicates whether (Yes) or not (No) there is previously published evidence that gene expression is altered by hypoxia. The column headed CREB indicates whether (Yes), or not (No) there is previously published evidence that gene expression is altered by CREB activation. The column headed HIF-1/HRE indicates whether (Yes) or not (No) there is previously published evidence that gene expression is altered by HIF-1 binding to a hypoxia response element in its promoter. See online supplement for detailed bibliography.