Stem cell |
Cells with unlimited self renewal, dividing asymmetrically to produce an identical daughter cell and a more differentiated progenitor. |
Bone marrow stem cell |
Comprises hematopoietic and mesenchymal stem cells. |
Hematopoietic stem cell |
Stem cell able to form all cells of the blood lineage. |
Mesenchymal stem cell |
Stromal stem cell able to produce supporting cells including bone, fat, and cartilage. |
Fibroblast |
Main mature cell type involved in the production of the extracellular matrix and collagen of tissues. |
Myofibroblast |
Fibroblasts can be activated (e.g., by transforming growth factor β) to form these cells, which produce extracellular matrix but also have the ability to contract. Stain for α-smooth muscle actin. |
Fibrocytes |
Circulating peripheral cells of bone marrow origin. Often described as blood-derived fibroblasts. Express a characteristic pattern of markers including the leukocyte common antigen CD45, the hematopoietic marker CD34, and collagen 1. |