Table 1.
n | % | |
---|---|---|
High Risk for Weight Gain | ||
Lithium | 40 | 49.4 |
Divalproex | 21 | 25.9 |
Olanzapine | 12 | 14.8 |
Quetiapine | 8 | 9.9 |
Risperidone | 6 | 7.4 |
MAOIs (tranylcypromine) | 1 | 1.2 |
Tricyclic antidepressants (desipramine) | 1 | 1.2 |
Paroxetine | 4 | 4.9 |
Insulin | 2 | 2.5 |
Beta blockers | 6 | 7.4 |
Lower Risk or No Risk for Weight Gain | ||
Carbamazepine, lamotrigine, topiramate, gabapentin | 35 | 43.2 |
Aripiprazole, ziprasidone | 26 | 32.1 |
First generation antipsychotics (perphenazine) | 1 | 1.2 |
SSRIs (except paroxetine) | 20 | 24.7 |
Atypical antidepressants (no subject was taking mirtzapine) | 17 | 21.0 |
Benzodiazepine anxiolytics/hypnotics | 28 | 34.6 |
Opiates | 2 | 2.5 |
Stimulants/ADHD medications | 4 | 4.9 |
Antiparkinsonian medications | 5 | 6.2 |
Other non-psychotropic medications | 49 | 60.5 |
MAOI = Monoamine Oxidase Inhibitor; SSRI = Serotonin-Specific Reuptake Inhibitor; ADHD = Attention-Deficit Hyperactivity Disorder.
Classification of medications as high risk versus lower risk or no risk was based on data from the following empirical studies and literature reviews: Fava (2000); Malhi et al. (2001); Jallon and Picard (2001); Pischon and Sharma (2001); Vania et al. (2002); Keck and McElroy (2003); Heller (2004). The majority of patients (86.4%; n = 70) were taking ≥ 1 psychotropic medication at entry into the current study; 60.5% (n = 49) also were taking at least one non-psychotropic medication.