Figure 1.

Changes of Rl in short-term– and long-term–challenged mice. Increasing concentrations of nebulized MCh were administered through the tracheal cannula 48 h after the last OVA challenge. (A) Groups of mice treated with anti-RANTES antibody or control rat IgG. (B) Groups of mice treated with RANTES or PBS. Data represent mean ± SEM. *P < 0.05 between groups indicated or S/7C (sensitized, seven challenges) versus 7C (seven challenges) mice. **P < 0.01 between groups indicated or S/7C versus 7C mice. ^##P < 0.01 compared with S/3C (sensitized, three challenges) with 3C (three challenges) mice. 3C and 7C: nonsensitized mice exposed to three or seven OVA challenges. S/3C and S/7C: sensitized mice exposed to three or seven OVA challenges.