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. 2006 Mar 16;35(2):175–181. doi: 10.1165/rcmb.2005-0239OC

Figure 1.

Figure 1.

CCL2 is not required for the development of FITC- or bleomycin-induced fibrosis. (A) WT, CCR2−/−, or CCL2−/− mice were injected with FITC or saline on Day 0. On Day 21, lungs were harvested and total lung collagen content was determined by Sircol assay (n = 6 group). Data are presented as the mean of the value of collagen in the saline-treated samples subtracted from the collagen values in FITC-treated mice. CCR2−/− mice are protected from FITC-induced fibrosis (P < 0.02), whereas CCL2 −/− mice are not. Data represent three separate experiments. (B) The same experiment was repeated using bleomycin as the fibrotic stimulus. CCR2−/− mice are protected from bleomycin-induced pulmonary fibrosis (P < 0.05), but CCL2−/− mice were not.