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Levels of total serum IgE are significantly reduced in SLAM−/− OVA mice compared with SLAM+/+ OVA control mice. Blood was extracted by cardiac puncture, and total serum IgE was measured by ELISA 24 h after aerosol challenge as described in Materials and Methods. Data are shown as mean IgE concentration in ng/ml ± SEM (n = 2 experiments; 6–11 mice per group).
