TABLE 2.
GENES DOWN-REGULATED IN AIRWAY EPITHELIUM WITH HYPEROXIA IN VIVO
| Affymetrix ID | Accession No. | Symbol | Gene | Ratio* | P Value† |
|---|---|---|---|---|---|
| 221904_at | NM_144635 | MGC21688 | Hypothetical protein MGC21688 | 0.73 | 2.5 × 10−3 |
| 219001_s_at | NM_024345 | MGC10765 | Hypothetical protein MGC10765 | 0.66 | 3.4 × 10−3 |
| 221774_x_at | NM_017569 | FAM48A | Family with sequence similarity 48, member A | 0.64 | 3.7 × 10−3 |
| 32091_at | NM_014655 | KIAA0446 | KIAA0446 gene product | 0.81 | 7.2 × 10−3 |
| 204676_at | NM_015421 | DKFZP564K2062 | DKFZP564K2062 protein | 0.67 | 1.2 × 10−2 |
| 204252_at | NM_001798 | CDK2 | Cyclin-dependent kinase 2 | 0.72 | 1.3 × 10−2 |
| 212083_at | NM_144582 | TEX261 | Testis expressed gene 261 | 0.85 | 1.3 × 10−2 |
| 200856_x_at | NM_006311 | NCOR1 | Nuclear receptor co-repressor 1 | 0.61 | 1.6 × 10−2 |
| 204180_s_at | NM_014007 | ZNF297B | Zinc finger protein 297B | 0.80 | 1.7 × 10−2 |
| 206115_at | NM_004430 | EGR3 | Early growth response 3 | 0.40 | 1.8 × 10−2 |
| 213816_s_at | NM_000245 | MET | Met proto-oncogene (hepatocyte growth factor receptor) | 0.67 | 1.9 × 10−2 |
| 201860_s_at | NM_000930 | PLAT | Plasminogen activator, tissue | 0.64 | 1.9 × 10−2 |
| 219801_at | NM_030580 | ZNF34 | Zinc finger protein 34 (KOX 32) | 0.69 | 2.1 × 10−2 |
| 215246_at | NM_016648 | HDCMA18P | HDCMA18P protein | 0.77 | 2.3 × 10−2 |
| 203934_at | NM_002253 | KDR | Kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.75 | 2.5 × 10−2 |
| 201668_x_at | NM_002356 | MARCKS | Myristoylated alanine-rich protein kinase C substrate | 0.83 | 2.7 × 10−2 |
| 37433_at | NM_004671 | PIAS2 | Protein inhibitor of activated STAT2 | 0.64 | 2.7 × 10−2 |
| 201270_x_at | NM_015332 | KIAA1068 | KIAA1068 protein | 0.84 | 2.8 × 10−2 |
| 206533_at | NM_000745 | CHRNA5 | Cholinergic receptor, nicotinic, α polypeptide 5 | 0.72 | 2.9 × 10−2 |
| 214801_at | NM_145034 | LOC163590 | AF464140 | 0.66 | 3.0 × 10−2 |
| 216396_s_at | NM_004879 | EI24 | Etoposide induced 2.4 mRNA | 0.78 | 3.0 × 10−2 |
| 209594_x_at | NM_002784 | PSG9 | Pregnancy-specific β1-glycoprotein 9 | 0.78 | 3.0 × 10−2 |
| 217156_at | NM_000182 | HADHA | Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), α subunit | 0.66 | 3.1 × 10−2 |
| 219685_at | NM_021637 | FLJ14084 | Hypothetical protein FLJ14084 | 0.73 | 3.2 × 10−2 |
| 210653_s_at | NM_000056 | BCKDHB | Branched chain keto acid dehydrogenase E1, β polypeptide (maple syrup urine disease) | 0.79 | 3.2 × 10−2 |
| 217866_at | NM_024811 | FLJ12529 | Pre-mRNA cleavage factor I, 59-kD subunit | 0.86 | 3.5 × 10−2 |
| 213058_at | AK092338 | LOC283585 | Transcribed locus, weakly similar to XP_375099.1 hypothetical protein LOC283585 | 0.63 | 3.6 × 10−2 |
| 214699_x_at | NM_015610 | DKFZP434J154 | WIPI49-like protein 2 | 0.72 | 3.6 × 10−2 |
| 217682_at | NM_014117 | PRO0149 | PRO0149 protein | 0.80 | 3.6 × 10−2 |
| 205741_s_at | NM_001392 | DTNA | Dystrobrevin, α | 0.72 | 3.9 × 10−2 |
| 218862_at | NM_024701 | ASB13 | Ankyrin repeat and SOCS box-containing 13 | 0.82 | 4.1 × 10−2 |
| 214119_s_at | NM_000801 | FKBP1A | FK506 binding protein 1A, 12 kD | 0.68 | 4.1 × 10−2 |
| 219889_at | NM_005479 | FRAT1 | Frequently rearranged in advanced T-cell lymphomas | 0.81 | 4.2 × 10−2 |
| 207805_s_at | NM_002813 | PSMD9 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | 0.79 | 4.4 × 10−2 |
| 214080_x_at | NM_002743 | PRKCSH | Protein kinase C substrate 80K-H | 0.82 | 4.4 × 10−2 |
| 214035_x_at | AK131084 | LOC399491 | LOC399491 protein | 0.65 | 4.6 × 10−2 |
| 205550_s_at | NM_004899 | BRE | Bain and reproductive organ-expressed (TNFRSF1A modulator) | 0.80 | 4.7 × 10−2 |
| 212864_at | NM_003818 | CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidyltransferase) 2 | 0.80 | 4.9 × 10−2 |
*
Hyperoxia/normoxia ratio of the median.
†
Welch t test performed to determine significant genes on the filtered set of 9,787 genes.