TABLE 3.

GENES UP-REGULATED IN AIRWAY EPITHELIUM WITH HYPEROXIA IN VIVO

Affymetrix ID	Accession No.	Symbol	Gene	Ratio*	P Value†
219933_at	NM_016066	GLRX2	Glutaredoxin 2	1.57	1.8 × 10−3
201177_s_at	NM_005499	UBA2	SUMO-1 activating enzyme subunit 2	1.34	5.8 × 10−3
206020_at	NM_004232	SOCS6	Suppressor of cytokine signaling 6	1.36	6.1 × 10−3
219767_s_at	NM_005111	CRYZL1	Crystalline, zeta (quinone reductase)-like 1	1.26	8.0 × 10−3
213000_at	NM_015358	ZCWCC3	Zinc finger, CW-type with coiled-coil domain 3	1.53	8.1 × 10−3
205288_at	NM_003672	CDC14A	CDC14 cell division cycle 14 homolog A (S. cerevisiae)	1.78	8.6 × 10−3
201801_s_at	NM_004955	SLC29A1	Solute carrier family 29 (nucleoside transporters), member 1	1.31	8.9 × 10−3
200608_s_at	NM_006265	RAD21	RAD21 homolog (S. pombe)	1.29	9.3 × 10−3
209146_at	NM_006745	SC4MOL	Sterol-C4-methyl oxidase-like	1.22	9.9 × 10−3
211746_x_at	NM_148976	PSMA1	Proteasome (prosome, macropain) subunit, alpha type, 1	1.41	1.0 × 10−2
213375_s_at	NM_052818	CG018	Hypothetical gene CG018	1.46	1.1 × 10−2
204449_at	NM_005388	PDCL	Phosducin-like	1.59	1.1 × 10−2
203827_at	NM_017983	FLJ10055	Hypothetical protein FLJ10055	1.37	1.1 × 10−2
212388_at	XM_371254	USP24	Ubiquitin specific protease 24	1.41	1.1 × 10−2
212510_at	NM_015141	KIAA0089	KIAA0089 protein	1.36	1.3 × 10−2
203855_at	NM_014969	KIAA0893	KIAA0893 protein	1.21	1.4 × 10−2
201816_s_at	NM_001483	GBAS	Glioblastoma amplified sequence	1.29	1.5 × 10−2
221182_at	NM_025063	FLJ23550	Hypothetical protein FLJ23550	1.29	1.5 × 10−2
212929_s_at	NM_001005751	LOC387680, FLJ10824	Similar to KIAA0592 protein hypothetical protein FLJ10824	1.30	1.6 × 10−2
201803_at	NM_000938	POLR2B	Polymerase (28) II (DNA directed) polypeptide B, 140 kD	1.16	1.7 × 10−2
209448_at	NM_006410	HTATIP2	HIV-1 Tat interactive protein 2, 30 kD	1.17	1.8 × 10−2
211953_s_at	NM_002271	KPNB3	Karyopherin (importin) β 3	1.49	1.9 × 10−2
208678_at	NM_001696	ATP6V1E1	ATPase, H+ transporting, lysosomal 31 kD, V1 subunit E isoform 1	1.32	2.0 × 10−2
217851_s_at	NM_016045	C20orf45	Chromosome 20 open reading frame 45	1.46	2.1 × 10−2
208788_at	NM_021814	ELOVL5	ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)	1.25	2.1 × 10−2
201784_s_at	NM_014267	SMAP	Small acidic protein	1.49	2.2 × 10−2
65493_at	NM_022070	ABC1	Amplified in breast cancer 1	1.44	2.2 × 10−2
200775_s_at	NM_002140	HNRPK	Heterogeneous nuclear ribonucleoprotein K	1.56	2.3 × 10−2
213530_at	BC022977	RAB3GAP	RAB3 GTPase-activating protein	1.16	2.4 × 10−2
213246_at	XM_058628	C14orf109	Chromosome 14 open reading frame 109	1.36	2.4 × 10−2
217853_at	NM_022748	TENS1	Tensin-like SH2 domain containing 1	1.44	2.4 × 10−2
208848_at	NM_000671	ADH5	Alcohol dehydrogenase 5 (class III), chi polypeptide	1.69	2.4 × 10−2
208638_at	NM_005742	TXNDC7	Thioredoxin domain containing 7 (protein disulfide isomerase)	1.31	2.4 × 10−2
212819_at	NM_016114	ASB1	Ankyrin repeat and SOCS box-containing 1	1.62	2.4 × 10−2
215884_s_at	NM_013444	UBQLN2	Ubiquilin 2	1.43	2.5 × 10−2
212543_at	XM_166300	AIM1	Absent in melanoma 1	1.14	2.5 × 10−2
208736_at	NM_005719	ARPC3	Actin related protein 2/3 complex, subunit 3, 21kDa	1.18	2.7 × 10−2
204201_s_at	NM_006264	PTPN13	Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	1.26	2.7 × 10−2
207483_s_at	NM_018448	TIP120A	TBP-interacting protein	1.25	2.7 × 10−2
208857_s_at	NM_005389	PCMT1	Protein-L-isoaspartate (D-aspartate) O-methyltransferase	1.32	2.7 × 10−2
219800_s_at	NM_024838	THNSL1	Threonine synthase-like 1 (bacterial)	1.78	2.8 × 10−2
212519_at	NM_003341	UBE2E1	Ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	1.29	2.8 × 10−2
220495_s_at	NM_024715	C5orf14	Chromosome 5 open reading frame 14	1.36	2.8 × 10−2
209043_at	NM_005443	PAPSS1	3′-phosphoadenosine 5′-phosphosulfate synthase 1	1.22	2.9 × 10−2
211936_at	NM_005347	HSPA5	Heat shock 70-kD protein 5 (glucose-regulated protein, 78 kD)	1.44	2.9 × 10−2
218333_at	NM_016041	F-LANa	Carcinoma-related gene	1.50	2.9 × 10−2
217737_x_at	NM_016407	C20orf43	Chromosome 20 open reading frame 43	1.16	2.9 × 10−2
202872_at	NM_001695	ATP6V1C1	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1	1.48	3.0 × 10−2
213848_at	NM_001947	DUSP7	Dual specificity phosphatase 7	1.30	3.0 × 10−2
202271_at	NM_015176	KIAA0483	KIAA0483 protein	1.35	3.0 × 10−2
212698_s_at	NM_144710	SEPT10	Septin 10	1.25	3.1 × 10−2
201676_x_at	NM_148976	PSMA1	Proteasome (prosome, macropain) subunit, alpha type, 1	1.17	3.1 × 10−2
206262_at	NM_000669	ADH1C	Alcohol dehydrogenase 1C (class I), gamma polypeptide	1.74	3.1 × 10−2
203181_x_at	NM_182691	SRPK2	SFRS protein kinase 2	1.60	3.1 × 10−2
211760_s_at	NM_003762	VAMP4	Vesicle-associated membrane protein 4	1.21	3.2 × 10−2
200979_at	NM_000284	PDHA1	Pyruvate dehydrogenase (lipoamide) alpha 1	1.26	3.2 × 10−2
201443_s_at	NM_005765	ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	1.30	3.2 × 10−2
209273_s_at	NM_030940	HBLD2	HESB like domain containing 2	1.33	3.3 × 10−2
212936_at	NM_032042	DKFZP564D172	Hypothetical protein DKFZp564D172	1.41	3.3 × 10−2
212841_s_at	BC021714	PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)	1.39	3.5 × 10−2
222016_s_at	NM_145909	ZNF323	Zinc finger protein 323	1.82	3.5 × 10−2
211744_s_at	NM_001779	CD58	CD58 antigen, (lymphocyte function-associated antigen 3)	1.46	3.6 × 10−2
201021_s_at	NM_006870	DSTN	Destrin (actin depolymerizing factor)	1.54	3.6 × 10−2
210968_s_at	NM_020532	RTN4	Reticulon 4	1.19	3.7 × 10−2
209174_s_at	NM_017730	FLJ20259	FLJ20259 protein	1.35	3.7 × 10−2
202868_s_at	NM_006627	POP4	Processing of precursor 4, RNase P/MRP subunit (S. cerevisiae)	1.21	3.7 × 10−2
201592_at	NM_003756	EIF3S3	Eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa	1.24	3.7 × 10−2
211971_s_at	NM_133259	LRPPRC	Leucine-rich PPR-motif containing	1.24	3.8 × 10−2
203773_x_at	NM_000712	BLVRA	Biliverdin reductase A	1.49	3.8 × 10−2
203218_at	NM_002752	MAPK9	Mitogen-activated protein kinase 9	1.47	3.8 × 10−2
209004_s_at	NM_012161	FBXL5	F-box and leucine-rich repeat protein 5	1.18	3.8 × 10−2
202049_s_at	NM_005095	ZNF262	Zinc finger protein 262	1.29	3.8 × 10−2
213940_s_at	NM_015033	FNBP1	Formin binding protein 1	1.47	3.9 × 10−2
200992_at	NM_006391	IPO7	Importin 7	1.28	3.9 × 10−2
215440_s_at	XM_043653	BEXL1	Brain expressed X-linked-like 1	1.41	3.9 × 10−2
202474_s_at	NM_005334	HCFC1	Host cell factor C1 (VP16-accessory protein)	1.27	4.0 × 10−2
221637_s_at	NM_024099	MGC2477	Hypothetical protein MGC2477	1.34	4.0 × 10−2
200684_s_at	NM_003347	UBE2L3	Ubiquitin-conjugating enzyme E2L 3	1.38	4.1 × 10−2
219751_at	NM_024860	FLJ21148	Hypothetical protein FLJ21148	1.39	4.1 × 10−2
202854_at	NM_000194	HPRT1	Hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)	1.30	4.1 × 10−2
209340_at	NM_003115	UAP1	UDP-N-acteylglucosamine pyrophosphorylase 1	1.26	4.2 × 10−2
209034_at	NM_006813	PNRC1	Proline-rich nuclear receptor coactivator 1	1.94	4.2 × 10−2
200780_x_at	NM_000516	GNAS	GNAS complex locus	1.31	4.3 × 10−2
200941_at	NM_001537	HSBP1	Heat shock factor binding protein 1	1.09	4.3 × 10−2
212956_at	XM_093895	KIAA0882	KIAA0882 protein	1.27	4.3 × 10−2
201200_at	NM_003851	CREG	Cellular repressor of E1A-stimulated genes	1.44	4.4 × 10−2
218065_s_at	NM_020644	C11orf15	Chromosome 11 open reading frame 15	1.19	4.6 × 10−2
202865_at	NM_001002762	DNAJB12	DnaJ (HSP40) homolog, subfamily B, member 12	1.27	4.6 × 10−2
202193_at	NM_005569	LIMK2	LIM domain kinase 2	1.24	4.6 × 10−2
217731_s_at	NM_021999	ITM2B	Integral membrane protein 2B	1.74	4.6 × 10−2
206158_s_at	NM_003418	ZNF9	Zinc finger protein 9	1.27	4.7 × 10−2
209005_at	NM_012161	FBXL5	F-box and leucine-rich repeat protein 5	1.36	4.7 × 10−2
209063_x_at	NM_006451	PAIP1	Poly(A) binding protein interacting protein 1	1.17	4.8 × 10−2
212017_at	AL137406	LOC130074	Hypothetical protein LOC130074	1.20	5.0 × 10−2
201202_at	NM_002592	PCNA	Proliferating cell nuclear antigen	1.33	5.0 × 10−2

^*Hyperoxia/normoxia ratio of the median.

^†Welch t test performed to determine significant genes on the filtered set of 9,787 genes.