TABLE 4.
GOMINER CATEGORIES OF GENES MODULATED BY HYPEROXIA IN HUMAN AIRWAY EPITHELIUM IN VIVO
| Total* | Under* | Over* | P Value | |
|---|---|---|---|---|
| Molecular Function | ||||
| Catalytic activity | ||||
| Nucleotidyl transferase activity | 63 | 1 | 4 | 4 × 10−3 |
| Protein tyrosine phosphatase activity | 39 | 0 | 4 | 4 × 10−3 |
| Protein tyrosine/serine/threonine phosphatase activity | 20 | 0 | 2 | 4.2 × 10−2 |
| Ubiquitin conjugating enzyme activity | 18 | 0 | 2 | 3.5 × 10−2 |
| Oxidoreductase activity | ||||
| Acting on aldehyde oroxo group of donors | 19 | 1 | 1 | 4 × 10−2 |
| Formaldehyde dehydrogenase (glutathione) activity | 1 | 0 | 1 | 1.6 × 10−2 |
| Alcohol dehydrogenase activity | 6 | 0 | 2 | 4 × 10−3 |
| Transcription cofactor activity | 134 | 2 | 4 | 2.3 × 10−2 |
| Corepressor activity | 46 | 1 | 2 | 4 × 10−2 |
| Small GTPase binding | 18 | 0 | 2 | 3.5 × 10−2 |
| Ran GTPase binding | 4 | 0 | 2 | 2 × 10−3 |
| Unknown | 235 | 2 | 7 | 1.5 × 10−2 |
| Biological Process | ||||
| Regulation of DNA replication | 8 | 1 | 1 | 7 × 10−3 |
| Proteolysis during cellular protein catabolism | 93 | 1 | 4 | 1.8 × 10−2 |
| Ubiquitin-dependent protein catabolism | 81 | 1 | 4 | 1 × 10−2 |
| Protein import into nucleus, docking | 13 | 0 | 2 | 1.9 × 10−2 |
| Protein modification | 679 | 5 | 13 | 2.6 × 10−2 |
| Phosphorus metabolism | 370 | 3 | 8 | 3.9 × 10−2 |
| Protein amino acid dephosphorylation | 67 | 0 | 4 | 2.4 × 10−2 |
*
Number of genes modulated by hyperoxia and number of genes in each category on U133 array. Over- or under-representation of functional categories according to the GO classification are determined by using Fisher's exact test. Categories containing more than two genes and a P value < 0.05 are represented.