TABLE 1.

IL-10 REDUCES CELLULAR INFLAMMATION AND PROINFLAMMATORY CYTOKINE PRODUCTION IN WHOLE-LUNG LAVAGE FLUID AFTER ACUTE LPS EXPOSURE

	IL-10–Deficient	C57BL/6	IL-10–Deficient Expressing hIL-10	C57BL/6 Expressing hIL-10
Total cells /ml lavage fluid	1,134.0 ± 169.1	469.5 ± 45.8*	†594.4 ± 61.5	245.4 ± 43.5‡
Neutrophils/ml lavage fluid	1,082.6 ± 162.6	446.9 ± 46*	563 ± 59.8*	232.6 ± 43.5‡
TNF-α (pg/ml lavage fluid)	4,284.8 ± 545.9	2,864.6 ± 297.8†	1,404.3 ± 419.4*	564.9 ± 105.6‡

Definition of abbreviation: hIL = human IL.

Data are expressed as mean ± SEM.

^*P < 0.05 compared to IL-10–deficient mice.

^†P < 0.01 compared to IL-10–deficient mice.

^‡P < 0.001 compared to IL-10–deficient mice.